The United States boasts a dynamic and expansive healthcare sector, encompassing a wide array of organizations from pharmaceutical giants to innovative telehealth providers. As of 2025, the following ten companies stand out for their significant contributions to healthcare delivery, innovation, and financial performance.
1. UnitedHealth Group
UnitedHealth Group, headquartered in Eden Prairie, Minnesota, is a diversified healthcare company offering a broad spectrum of services. Its two primary divisions are UnitedHealthcare, providing health benefits, and Optum, offering information and technology-enabled health services. With a market capitalization of approximately $460.3 billion as of December 2024, UnitedHealth Group is a leader in the healthcare industry.
Despite recent earnings challenges, UnitedHealth Group remains a cornerstone in the healthcare sector, demonstrating resilience and adaptability in a complex regulatory environment.
2. CVS Health Corporation
CVS Health Corporation, based in Woonsocket, Rhode Island, operates as an integrated healthcare services provider. The company encompasses CVS Pharmacy, CVS Caremark, and Aetna, offering services ranging from retail pharmacy to health insurance. In 2025, CVS Health has shown strong performance, with its stock price reflecting investor confidence.
CVS Health’s comprehensive approach to healthcare delivery positions it as a significant player in the industry, addressing various aspects of patient care and wellness.
3. McKesson Corporation
McKesson Corporation, headquartered in Irving, Texas, is a global leader in healthcare supply chain management solutions, retail pharmacy, community oncology and specialty care, and healthcare information technology. In 2024, McKesson reported revenues of $308.9 billion, making it one of the largest companies in the United States by revenue.
McKesson’s extensive distribution network ensures the efficient delivery of pharmaceuticals and medical products, playing a critical role in the healthcare infrastructure.
4. Johnson & Johnson
Johnson & Johnson, based in New Brunswick, New Jersey, is a multinational corporation engaged in the research and development, manufacture, and sale of a broad range of products in the healthcare field. The company’s operations are divided into three segments: Consumer Health, Pharmaceutical, and MedTech. In 2023, Johnson & Johnson spun off its consumer health division into a new company, Kenvue, allowing it to focus more on pharmaceuticals and medical devices.
With a history dating back to 1886, Johnson & Johnson continues to be a leader in medical innovation and patient care.
5. Cigna Group
Cigna Group, headquartered in Bloomfield, Connecticut, is a global health service company offering health, pharmacy, dental, supplemental insurance, and Medicare plans to individuals, families, and businesses. As of April 2025, Cigna’s stock price reflects its strong market position and investor confidence.
Cigna’s commitment to improving health outcomes and affordability makes it a key player in the managed healthcare space.
6. Humana Inc.
Humana Inc., based in Louisville, Kentucky, is a leading health and well-being company focused on providing Medicare Advantage plans, Medicaid, and other health insurance products. In 2025, Humana continues to expand its services, emphasizing integrated care and personalized health solutions.
Humana’s focus on senior care and chronic condition management positions it as a vital contributor to the healthcare system.
7. Pfizer Inc.
Pfizer Inc., headquartered in New York City, is a global pharmaceutical corporation known for developing and manufacturing medicines and vaccines. In 2023, Pfizer’s revenue was $58.5 billion, a decrease from the previous year due to declining COVID-19 product sales.
Despite recent revenue fluctuations, Pfizer’s robust pipeline and commitment to innovation maintain its status as a pharmaceutical leader.
8. Eli Lilly and Company
Eli Lilly and Company, based in Indianapolis, Indiana, is a pharmaceutical company specializing in developing medications for various diseases, including diabetes, cancer, and mental health conditions. As of October 2024, Eli Lilly achieved a market capitalization of $842 billion, the highest ever for a drug company.
Eli Lilly’s focus on innovative treatments and significant investment in research and development underscore its leadership in the pharmaceutical industry.
9. Abbott Laboratories
Abbott Laboratories, headquartered in Abbott Park, Illinois, is a diversified healthcare company engaged in the discovery, development, manufacture, and sale of a broad and diversified line of health care products. Abbott’s product lines include diagnostics, medical devices, nutritionals, and branded generic medicines.
Abbott’s commitment to advancing medical technology and improving patient care solidifies its position in the healthcare sector.
10. Teladoc Health
Teladoc Health, based in Purchase, New York, is a multinational telemedicine and virtual healthcare company. It provides a platform for remote medical consultations and services, serving over 80 million people across its virtual care products as of 2023.
Teladoc’s emphasis on accessible, remote healthcare solutions positions it at the forefront of digital health innovation.